Schedule Notes

In the 1981 NFL season, the San Francisco 49ers opened play and ended it in Detroit with wins, first in the “reg” and then (26-21) vs the Cincinnati Bengals in the Super Bowl.

That season the Niners also defeated the Bengals in the regular season.

In 2021, again SF opened the season with a win at Detroit and nearly faced the Bengals for a third time in the Supe.